What Should You Expect During PRP Therapy for ED?

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Dr. James D. Fontaine

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10/10/2026

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Changes in erection firmness, stamina, or sexual performance can be frustrating, especially when they begin affecting confidence and intimacy. PRP therapy for ED offers a nonsurgical approach that uses platelet-rich plasma from your own blood to support healthier erectile tissue and circulation. At Fontaine MD Aesthetics and Anti-Aging Medicine in San Diego, CA, Dr. James D. Fontaine offers Natural Injection Therapy for men interested in addressing erectile dysfunction without surgery. 

Treatment generally involves a blood draw, preparation of the platelet-rich plasma, numbing the treatment area, and carefully placing penile injections. The appointment typically takes about an hour, while the injections take only a few minutes. 

How does PRP therapy for ED work? 

Platelet-rich plasma contains concentrated platelets and growth factors that play a role in the body’s natural healing and tissue-repair processes. During Natural Injection Therapy, PRP is introduced into targeted penile tissue with the goal of supporting vascular tissue, circulation, and erectile function. Because healthy penile blood flow is an important part of achieving and maintaining an erection, improving circulation may contribute to firmer, more sustainable erections and enhanced sexual function. 

Dr. Fontaine evaluates overall health, symptoms, and treatment goals before recommending this approach, since erectile dysfunction can have several contributing factors and the right sexual health treatment can vary from one man to another. 

What happens during Natural Injection Therapy? 

Understanding what to expect during PRP therapy for ED can make the appointment feel much more straightforward. Treatment begins with a blood draw, which allows the platelet-rich plasma to be separated and prepared for injection. A topical anesthetic is then applied to the treatment area to improve comfort before the PRP is administered. 

The injections may cause a slight pinching sensation or pressure, but the numbing medication is intended to minimize discomfort. For men considering erectile dysfunction treatment in San Diego, Dr. Fontaine also provides preparation and aftercare instructions so there is a clear understanding of each stage of the procedure. 

What should you expect after Natural Injection Therapy? 

One advantage of PRP treatment is that there is typically little disruption to your normal schedule afterward. Some men may notice mild tenderness or soreness around the injection areas, but significant downtime is generally not expected. Improvements are not necessarily immediate because the treatment is intended to support gradual changes within the tissue. 

Initial changes may become noticeable within several weeks, while the full response can continue developing over the following months. Following Dr. Fontaine’s aftercare recommendations is important, and results can vary depending on factors such as overall health, circulation, and the underlying causes contributing to erectile dysfunction. 

Explore a regenerative approach to sexual wellness 

PRP may be considered when erections are weaker than they once were, maintaining firmness has become more difficult, or traditional ED medications have not provided the desired experience. It may also appeal to men who want to explore a regenerative approach alongside other options for improving sexual wellness. Since erectile dysfunction can be connected to vascular health, hormones, medications, and other medical factors, an evaluation can help identify which approach makes sense for your needs. 

At Fontaine MD Aesthetics and Anti-Aging Medicine in San Diego, CA, Dr. James D. Fontaine can discuss Natural Injection Therapy, review your health history, and determine whether this treatment may fit your goals. Contact us today to schedule a consultation and explore options for improving erectile function, circulation, and sexual confidence.

When I came to Dr. Fontaine several years ago, I was going into early menopause and experiencing so many symptoms. Hot flashes, fatigue, pain, brain fog, and depression that were being dismissed by my regular doctors. Dr. Fontaine was truly a godsend. He listened, took my concerns seriously, and helped me create a plan that worked for my body. Over time, we adjusted my medication, and I now feel 100% better. I’m so grateful for his care and support!

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Louise initially treated me with Botox at an MD clinic I had been using for years. I was so pleased with my results, when she moved to Fontaine MD I followed her even though it was much farther away. Recently, I decided to also get fillers and expressed to her my desire for a very natural and youthful look, and she nailed it! She is a licensed RN with an Art degree therefore she really understands the anatomy and symmetry of the face. She is welcoming, professional, never rushes and very skilled at injecting both Botox and fillers, I highly recommend Louise!I also highly recommend Fontaine MD, great Doctor, and staff in a lovely, serene setting. They were instrumental in aiding me in a 20+ lb weight loss (so easy) and I could not be more grateful. I feel and look so much better and have maintained my new weight. That is not easy for many 60-year-old females.

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Louise is absolutely wonderful to work with! I have seen her for both an IPL facial and Botox (my very first time!). She took the time to answer my questions, address my concerns, and put my mind at ease. I could sense that I was in the hands of someone who was going to take care of me. Louise cares about her clients and their desired outcomes. I have done IPL facials in the past with other providers and the procedures felt very harsh on my skin. With Louise, my skin was not red, bumpy, or painful after and my sunspots were treated effectively! I also trusted Louise with my first Botox experience. Louise made me feel both comfortable and excited about the natural but effective results I was hoping to have! I am thankful I found Louise and will be a returning client!

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Louise listened to my skin concerns, made recommendations and completed Botox and filler procedures that that made an amazing difference!

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Before seeing Dr. Fontaine, I had no idea I could feel better. I just assumed that as I got older, low energy, hormonal struggles, and general decline were just part of life—something I had to accept. Looking back, I realize how much I had normalized feeling exhausted, unmotivated, and off-balance. My energy had dipped, my sleep was inconsistent, and no matter what I did, things like weight gain and mood swings seemed unavoidable. I wasn’t in crisis—I just wasn’t thriving. Dr. Fontaine completely changed that. From the first appointment, he took the time to listen, evaluate my symptoms, and explain what was really happening in my body. Seeing my lab results was an eye-opener—I finally had real data that explained why I felt the way I did. Within a couple of months of starting treatment, I started feeling like myself again. My energy improved, my focus sharpened, and I finally started sleeping through the night. Over time, the changes were undeniable—I was stronger, my mood was steady, and I didn’t feel like I was constantly fighting against my own body. Dr. Fontaine has been with me every step of the way, adjusting my treatment as needed and making sure I feel my best. He’s thorough, knowledgeable, and truly invested in his patients' well-being. I never feel rushed in my appointments, and he always takes the time to answer my questions. I didn’t realize how much I was missing out on until I started feeling this good again. Now, I feel like I’ve regained the energy, confidence, and vitality I thought were long gone. I’m beyond grateful to Dr. Fontaine for helping me.

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